STUDY OF PREVALENCE OF HYPERHOMOCYSTEINEMIA IN CHRONIC KIDNEY DISEASEPATIENTS AT TERTIARY CARE HOSPITAL IN NORTHWEST MAHARASHTRA

Introduction-Chronic Kidney Disease is growing problem across all over world and India as well. Chronic kidney disease encompasses a spectrum of different pathophysiological processes associated with abnormal function progressive decline in glomerular filtration rate(GFR).The risk for cardiovascular (CVD) morbidity mortality remains high stages CKD, including patients hemodialysis. More CKD die CVD than the progression failure.The increase homocysteine level, referred hyperhomocysteinemia, highly prevalent an increased complications. Proposed mechanisms hyperhomocysteinemia failure due to reduced clearance total plasma (tHcy) secondary defective and/or extra metabolism tHcy deficiencies folate, vitamin B12, pyridoxal 5-phosphate (PLP). Aim-To study Serum Homocysteine levels Chronickidney estimate disease. Materials And Methods- All presenting clinical, biochemical ultrasound evidence chronic department medicine at tertiary care centre northern Maharashtra. Normal level was considered bebelow 15 umol/litre. Results- A 54 both sex were taken sample. Of 38 males 16 females .36 age range 41-60 . 32 stage 5 , 14 4 8 3 CKD. Hyperhomocysteinemia observed 78 % patients. Homocysteinemia maximum higher grade The associationbetween decreased GFR serum found be statistically significant. (p<0.05). Conclusion-Study concludes that commonly toxicthrombogenic amino acid which causes atherosclerosis diseases. Mortality diseases Hence early screening treatment should done prevent